| Definition | ECG Effects of drugs |
| No of environments | 22 |
| No of transitions | ~1220 |
The ECGDMMLD database contains data from a randomized, double-blind, 5-period crossover clinical trial in 22 healthy male and female subjects, 18 to 35 years of age, to compare the electrophysiological response of hERG potassium channel blocking drugs with and without the addition of late sodium or calcium channel blocking drugs. The 5 treatment periods are 1) dofetilide alone, 2) mexiletine with and without dofetilide, 3) lidocaine with and without dofetilide, 4) moxifloxacin with and without diltiazem and 5) placebo. During each treatment period, 12 blood samples for pharmacokinetic measurements are obtained with matched 12-lead ECG recordings.
An environment corresponds to a human. During each period, continuous ECGs were recorded at 500 Hz with an amplitude resolution of 2.5 μV using the Mortara Surveyor system (Mortara, Milwaukee, WI). From the continuous recording, triplicate 10‐second ECGs were extracted before the draw of each pharmacokinetic sample at 14 predefined time‐points: 1 point pre-dose (-0.5 h) and 13 points post‐dose (1.5, 2, 2.5, 3, 6.5, 7, 7.5, 8, 12, 12.5, 13, 13.5 and 24 h), during which the subjects were resting in a supine position for 10 minutes.
| Example observations | Mainly ~10 features extracted from ECG signals |
| Example actions | Dofetilide Lidocaine Mexiletine Moxifloxacin |
| Example reward | Tpeak-Tend interval |